The benefit of participating to clinical research

N Hébert-Croteau; J Brisson; J Lemaire; J Latreille

doi:10.1007/s10549-005-0320-0

The benefit of participating to clinical research

Breast Cancer Res Treat. 2005 Jun;91(3):279-81. doi: 10.1007/s10549-005-0320-0.

Authors

N Hébert-Croteau¹, J Brisson, J Lemaire, J Latreille

Affiliation

¹ Direction des Systèmes de Soins et Services, Institut National de Santé Publique du Québec, 4835 ave. Christophe-Colomb, Qc, Montréal H2J 3G8, Canada. [email protected]

PMID: 15952061
DOI: 10.1007/s10549-005-0320-0

Abstract

We assessed the impact of participating to clinical research among 1727 women with localized breast cancer. Using as referent individuals not treated according to guidelines for systemic therapy, the adjusted hazard ratio of death was 0.70 (95% confidence interval (CI): 0.54,0.90, p-value: 0.006) in those treated according to current guidelines and 0.45 (95% CI: 0.27,0.73, p-value: 0.001) in participants to research. Participation to clinical trials results in a substantial gain in survival.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Biomedical Research / statistics & numerical data*
Breast Neoplasms* / epidemiology
Breast Neoplasms* / mortality
Breast Neoplasms* / therapy
Clinical Trials as Topic / statistics & numerical data*
Female
Humans
Survival Rate
Treatment Outcome