Abstract
A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Frameshift Mutation*
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Humans
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RNA, Viral / genetics
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Severe Acute Respiratory Syndrome / virology*
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Severe acute respiratory syndrome-related coronavirus / genetics*
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Severe acute respiratory syndrome-related coronavirus / isolation & purification*
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Viral Envelope Proteins
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Viral Proteins / genetics*
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Viroporin Proteins
Substances
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3a protein, SARS-CoV
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RNA, Viral
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Viral Envelope Proteins
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Viral Proteins
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Viroporin Proteins