Synthesis, characterisation and cytotoxicity of chloro derivatives of prenylnaphthohydroquinone

Bioorg Med Chem. 2005 Jun 1;13(11):3841-6. doi: 10.1016/j.bmc.2005.02.063.

Abstract

From the Diels-Alder adduct between alpha-myrcene and 2-chloro-1,4-benzoquinone, a family of chloro derivatives of prenylnaphthohydroquinone have been synthesised and evaluated for their cytotoxicity against 14 neoplastic cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Humans
  • Hydroquinones / chemical synthesis
  • Hydroquinones / chemistry*
  • Hydroquinones / pharmacology*
  • Jurkat Cells
  • Magnetic Resonance Spectroscopy
  • Spectrophotometry, Infrared

Substances

  • Antineoplastic Agents
  • Hydroquinones
  • prenylnaphthohydroquinone