Abstract
Primary squamous cell carcinoma (SCC) of the stomach is an extremely rare tumor and its pathogenesis is still unknown. We report a case of SCC of the stomach in a 69-year-old man. The patient's stomach contained an area of SCC surrounded by squamous metaplasia. To our knowledge, this is the first reported study to have investigated the pathogenesis of this tumor type by immunohistochemistry, liquid hybridization assay for human papilloma virus (HPV) infection, and polymerase chain reaction for Epstein-Barr virus (EBV) infection. These tests yielded proof of EBV infection in surgical specimens of the tumor. Therefore, we suggest that EBV infection may be involved in the pathogenesis of SCC arising in the stomach.
MeSH terms
-
Aged
-
Carcinoma, Squamous Cell / genetics*
-
Carcinoma, Squamous Cell / pathology*
-
Carcinoma, Squamous Cell / surgery
-
Carcinoma, Squamous Cell / virology
-
DNA, Viral / genetics
-
Epstein-Barr Virus Infections / genetics
-
Epstein-Barr Virus Infections / pathology
-
Epstein-Barr Virus Infections / surgery
-
Esophageal Neoplasms / genetics*
-
Esophageal Neoplasms / pathology*
-
Esophageal Neoplasms / surgery
-
Esophageal Neoplasms / virology
-
Esophagectomy
-
Esophagogastric Junction / pathology*
-
Esophagogastric Junction / virology
-
Esophagus / pathology
-
Esophagus / virology
-
Gastric Mucosa / pathology
-
Gastric Mucosa / virology
-
Gastroscopy
-
Humans
-
Immunoenzyme Techniques
-
Male
-
Metaplasia
-
Papillomaviridae / genetics
-
Papillomavirus Infections / genetics
-
Papillomavirus Infections / pathology
-
Papillomavirus Infections / surgery
-
Polymerase Chain Reaction
-
Stomach Neoplasms / genetics*
-
Stomach Neoplasms / pathology*
-
Stomach Neoplasms / surgery
-
Stomach Neoplasms / virology
-
Tumor Suppressor Protein p53 / genetics
Substances
-
DNA, Viral
-
Tumor Suppressor Protein p53