In search of an auditory engram

Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9359-64. doi: 10.1073/pnas.0503998102. Epub 2005 Jun 20.

Abstract

Monkeys trained preoperatively on a task designed to assess auditory recognition memory were impaired after removal of either the rostral superior temporal gyrus or the medial temporal lobe but were unaffected by lesions of the rhinal cortex. Behavioral analysis indicated that this result occurred because the monkeys did not or could not use long-term auditory recognition, and so depended instead on short-term working memory, which is unaffected by rhinal lesions. The findings suggest that monkeys may be unable to place representations of auditory stimuli into a long-term store and thus question whether the monkey's cerebral memory mechanisms in audition are intrinsically different from those in other sensory modalities. Furthermore, it raises the possibility that language is unique to humans not only because it depends on speech but also because it requires long-term auditory memory.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Auditory Perception*
  • Cerebral Cortex / metabolism
  • Female
  • Haplorhini
  • Hippocampus
  • Learning
  • Male
  • Memory
  • Memory, Short-Term
  • Models, Anatomic
  • Models, Neurological
  • Recognition, Psychology
  • Temporal Lobe / metabolism
  • Time Factors