Design and synthesis of protein superfamily-targeted chemical libraries for lead identification and optimization

Curr Med Chem. 2005;12(11):1239-81. doi: 10.2174/0929867054020936.

Abstract

This review chronicles original literature dating back to 1992 outlining the applications of parallel synthesis and combinatorial chemistry to the synthesis of compound libraries focused towards specific superfamilies of molecular targets. Target families that have received significant literature coverage include kinases, proteases, nuclear hormone receptors and cell surface receptors, notably GPCRs.

Publication types

  • Review

MeSH terms

  • Drug Design*
  • Drug Evaluation, Preclinical / methods*
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Protein Kinases / metabolism*
  • Receptors, Cytoplasmic and Nuclear / antagonists & inhibitors
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Receptors, G-Protein-Coupled / antagonists & inhibitors
  • Receptors, G-Protein-Coupled / metabolism*

Substances

  • Enzyme Inhibitors
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, G-Protein-Coupled
  • Protein Kinases