Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors

Ronald G Sherrill; Eric S Furfine; Richard J Hazen; John F Miller; David J Reynolds; Douglas M Sammond; Andrew Spaltenstein; Pat Wheelan; Lois L Wright

doi:10.1016/j.bmcl.2005.05.101

Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors

Bioorg Med Chem Lett. 2005 Aug 1;15(15):3560-4. doi: 10.1016/j.bmcl.2005.05.101.

Authors

Ronald G Sherrill¹, Eric S Furfine, Richard J Hazen, John F Miller, David J Reynolds, Douglas M Sammond, Andrew Spaltenstein, Pat Wheelan, Lois L Wright

Affiliation

¹ GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA. [email protected]

PMID: 15975788
DOI: 10.1016/j.bmcl.2005.05.101

Abstract

A series of novel N-alkoxy-arylsulfonamide HIV protease inhibitors with low picomolar enzyme activity and single digit nanomolar antiviral activity is disclosed.

MeSH terms

Benzene Derivatives / chemistry
Drug Design
Drug Resistance, Multiple, Viral
HIV Protease / drug effects
HIV Protease / metabolism*
HIV Protease Inhibitors / chemical synthesis*
HIV Protease Inhibitors / pharmacology*
Humans
Structure-Activity Relationship
Sulfonamides / chemical synthesis*
Sulfonamides / pharmacology
Virus Replication / drug effects

Substances

Benzene Derivatives
HIV Protease Inhibitors
Sulfonamides
HIV Protease