Abstract
Neurogenesis persists in the olfactory bulb (OB) of the adult mammalian brain. New interneurons are continually added to the OB from the subventricular zone (SVZ) via the rostral migratory stream (RMS). Here we show that secreted prokineticin 2 (PK2) functions as a chemoattractant for SVZ-derived neuronal progenitors. Within the OB, PK2 may also act as a detachment signal for chain-migrating progenitors arriving from the RMS. PK2 deficiency in mice leads to a marked reduction in OB size, loss of normal OB architecture, and the accumulation of neuronal progenitors in the RMS. These findings define an essential role for G protein-coupled PK2 signaling in postnatal and adult OB neurogenesis.
MeSH terms
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Animals
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Apoptosis
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Brain / cytology
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Brain / growth & development
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Brain / metabolism
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Cell Adhesion
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Cell Count
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Cell Line
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Cell Proliferation
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Cerebral Ventricles / cytology
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Cerebral Ventricles / physiology*
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Chemotactic Factors / physiology
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Chemotaxis
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Coculture Techniques
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Dopamine / physiology
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Gastrointestinal Hormones / metabolism*
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Gene Expression
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Interneurons / cytology
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Interneurons / physiology*
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Mice
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Mice, Inbred C57BL
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Neurons / cytology
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Neurons / physiology*
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Neuropeptides / metabolism*
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Olfactory Bulb / cytology*
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Olfactory Bulb / growth & development
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Olfactory Bulb / metabolism*
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Rats
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Rats, Sprague-Dawley
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Receptors, G-Protein-Coupled / genetics
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Receptors, G-Protein-Coupled / metabolism
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Signal Transduction*
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Stem Cells / physiology*
Substances
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Chemotactic Factors
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Gastrointestinal Hormones
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Neuropeptides
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Prok2 protein, mouse
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Receptors, G-Protein-Coupled
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Dopamine