Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling

Gene Expr Patterns. 2005 Dec;6(1):94-101. doi: 10.1016/j.modgep.2005.04.009. Epub 2005 Jun 23.

Abstract

The Notch signaling pathway has pleiotropic functions during mammalian embryogenesis. It is required for the patterning and differentiation of the presomitic and somitic paraxial mesoderm and of the neural tube. We used DNA-chip expression profiling and 2D-gel electrophoresis combined with peptide mass fingerprinting to identify genes and proteins differentially regulated in E10.5 Dll1 (delta-like 1, Delta1) mutant embryos. The differential expression profiling approach identified 47 regulated transcripts and 40 differentially expressed proteins. The majority of these genes has until now not been associated with Notch signaling. Subsequent whole-mount in situ hybridization confirmed that a subset of the identified transcripts has restricted and distinct patterns of expression in E10.5 mouse embryos. For most genes these expression patterns were affected in the presomitic mesoderm, in differentiating somites of Dll1 mutant embryos and in the neural tube and cells differentiating from it. Similar effects were observed in embryos homozygous for the Headturner (Htu) and pudgy (pu) mutations, which are alleles of the Notch ligands Jag1 and Dll3. The regulated expression of a subset of the proteins was validated by immunoblots. Remarkably six of the proteins down-regulated in Dll1 mutant embryos are proteasome subunits. The large set of regulated genes identified in this differential expression profiling approach is an important resource for further functional studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Patterning / genetics*
  • Calcium-Binding Proteins / genetics
  • Embryo, Mammalian / chemistry
  • Embryo, Mammalian / metabolism
  • Embryonic Development / genetics*
  • Gene Expression Profiling*
  • Gene Expression Regulation, Developmental
  • Intercellular Signaling Peptides and Proteins
  • Intracellular Signaling Peptides and Proteins / genetics
  • Jagged-1 Protein
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Mice
  • Mice, Mutant Strains
  • Mutation
  • Oligonucleotide Array Sequence Analysis
  • Proteins / analysis
  • Proteins / genetics
  • Proteins / metabolism
  • RNA, Messenger / analysis
  • RNA, Messenger / metabolism
  • Serrate-Jagged Proteins
  • Signal Transduction

Substances

  • Calcium-Binding Proteins
  • Dll3 protein, mouse
  • Intercellular Signaling Peptides and Proteins
  • Intracellular Signaling Peptides and Proteins
  • Jag1 protein, mouse
  • Jagged-1 Protein
  • Membrane Proteins
  • Proteins
  • RNA, Messenger
  • Serrate-Jagged Proteins
  • delta protein