Abstract
Association of the plasmid-mediated quinolone resistance determinant QnrA and the bla(VEB-1) gene was identified in a single Enterobacter cloacae isolate from K.-Bicêtre, France, and in 11 out of 23 bla(VEB-1)-positive enterobacterial isolates from Bangkok, Thailand. This result may explain in part the association between quinolone and extended-spectrum beta-lactam resistance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Conjugation, Genetic
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Drug Resistance, Bacterial / genetics*
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Enterobacter cloacae / drug effects*
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Enterobacter cloacae / enzymology
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Enterobacter cloacae / genetics
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Escherichia coli Proteins
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Humans
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Male
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Microbial Sensitivity Tests / methods
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Molecular Sequence Data
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Nalidixic Acid / pharmacology
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Plasmids / genetics*
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Quinolones / pharmacology*
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Sequence Analysis, DNA
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Escherichia coli Proteins
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Quinolones
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Nalidixic Acid
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beta-lactamase VEB-1, E coli
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beta-Lactamases
Associated data
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GENBANK/AY931017
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GENBANK/AY931018