Abstract
[reaction: see text] Nucleophile-loaded peptides have been evaluated as catalysts for the desymmetrization of glycerol derivatives through an enantioselective acylation process. Enantiomeric excesses of up to 97% have been obtained for the monoacylated products. A range of other substrates have been examined that shed light on the mechanistic basis of the desymmetrizations.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acylation
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Catalysis
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Glycerol* / analogs & derivatives
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Glycerol* / chemical synthesis
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Glycerol* / chemistry
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Indicators and Reagents
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Lipase / metabolism
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Molecular Structure
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Peptides / chemistry*
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Pseudomonas / enzymology
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Stereoisomerism
Substances
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Indicators and Reagents
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Peptides
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Lipase
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Glycerol