Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines

Michael J Alberti; Elizabeth P Auten; Karen E Lackey; Octerloney B McDonald; Edgar R Wood; Frank Preugschat; Geoffrey J Cutler; Laurie Kane-Carson; Wei Liu; David K Jung

doi:10.1016/j.bmcl.2005.05.100

Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines

Bioorg Med Chem Lett. 2005 Aug 15;15(16):3778-81. doi: 10.1016/j.bmcl.2005.05.100.

Authors

Michael J Alberti¹, Elizabeth P Auten, Karen E Lackey, Octerloney B McDonald, Edgar R Wood, Frank Preugschat, Geoffrey J Cutler, Laurie Kane-Carson, Wei Liu, David K Jung

Affiliation

¹ GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA.

PMID: 15993060
DOI: 10.1016/j.bmcl.2005.05.100

Abstract

The discovery, synthesis, potential binding mode, and in vitro kinase profile of several pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines as potent kinase inhibitors are discussed.

MeSH terms

Humans
Hydrogen Bonding
Molecular Structure
Protein Conformation
Protein Kinase Inhibitors / chemical synthesis*
Protein Kinase Inhibitors / chemistry
Protein Kinase Inhibitors / pharmacology*
Protein Kinases / drug effects*
Protein Structure, Tertiary
Pyrimidines / chemical synthesis*
Pyrimidines / chemistry
Pyrimidines / pharmacology*
Structure-Activity Relationship

Substances

Protein Kinase Inhibitors
Pyrimidines
Protein Kinases