Abstract
A novel indirubin analog, indirubin-5-nitro-3'-monoxime, inhibited cell proliferation against various human cancer cells. Additional studies indicate that the mechanism of action of this analog against human lung cancer cells might be to arrest cell cycle progression at the G2/M phase and induce apoptosis via p53- and mitochondria-dependent pathways. These data suggest that indirubin-5-nitro-3'-monoxime might be a novel candidate for development of anticancer agents.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibiotics, Antineoplastic / chemical synthesis
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Antibiotics, Antineoplastic / pharmacology
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Apoptosis / drug effects*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cyclin-Dependent Kinases / antagonists & inhibitors*
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Humans
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Indoles / chemical synthesis
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Indoles / pharmacology
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Interphase / drug effects
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Lung Neoplasms / drug therapy*
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Lung Neoplasms / pathology
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Structure-Activity Relationship
Substances
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Antibiotics, Antineoplastic
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Indoles
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Cyclin-Dependent Kinases
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indirubin