Abstract
Emerging evidence suggests that the proapoptotic kinase mammalian sterile 20-like kinase 2 (MST2) acts in a novel tumor suppression pathway. Recently, we showed that Raf-1 kinase sequesters and inhibits MST2 and that this event is critical for Raf-mediated cell survival. In this review, we summarize Raf control of MST2 and we outline a novel pathway involving the downstream effector proteins Salvador and Warts/Lats that may act to limit the positive effects of Raf-mitogen-activated protein kinase signaling in cancer cells.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis / physiology
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Humans
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Intracellular Signaling Peptides and Proteins
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Neoplasms / enzymology*
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Neoplasms / pathology
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Protein Serine-Threonine Kinases / metabolism*
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Proto-Oncogene Proteins c-raf / metabolism
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Serine-Threonine Kinase 3
Substances
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Intracellular Signaling Peptides and Proteins
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Stk4 protein, mouse
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STK4 protein, human
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Protein Serine-Threonine Kinases
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Proto-Oncogene Proteins c-raf
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STK3 protein, human
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Serine-Threonine Kinase 3
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Stk3 protein, mouse