The F1Fo-ATP synthase of Mycobacterium smegmatis is essential for growth

J Bacteriol. 2005 Jul;187(14):5023-8. doi: 10.1128/JB.187.14.5023-5028.2005.

Abstract

The F(1)F(o)-ATP synthase plays an important role in a number of vital cellular processes in plants, animals, and microorganisms. In this study, we constructed a DeltaatpD mutant of Mycobacterium smegmatis and demonstrated that atpD encoding the beta subunit of the F(1)F(o)-ATP synthase is an essential gene in M. smegmatis during growth on nonfermentable and fermentable carbon sources.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA Primers
  • Gene Deletion
  • Mycobacterium smegmatis / enzymology*
  • Mycobacterium smegmatis / genetics
  • Mycobacterium smegmatis / growth & development
  • Plasmids / genetics
  • Protein Subunits / genetics
  • Proton-Translocating ATPases / genetics*
  • Proton-Translocating ATPases / metabolism*

Substances

  • DNA Primers
  • Protein Subunits
  • Proton-Translocating ATPases