Abstract
Streptococcus mutans UA159, the genome sequence reference strain, exhibits nonlantibiotic bacteriocin (mutacin) activity. In this study, we have combined bioinformatic and mutational analyses to identify the ABC transporter designated NlmTE, which is required for mutacin biogenesis in strain UA159 as well as in another mutacin producer, S. mutans N.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP-Binding Cassette Transporters / chemistry
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ATP-Binding Cassette Transporters / genetics*
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ATP-Binding Cassette Transporters / metabolism*
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Amino Acid Sequence
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Bacteriocins / chemistry
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Bacteriocins / genetics*
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Bacteriocins / metabolism*
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Base Sequence
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DNA Primers
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Molecular Sequence Data
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Polymerase Chain Reaction
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Sequence Alignment
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Sequence Homology, Amino Acid
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Streptococcus mutans / genetics*
Substances
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ATP-Binding Cassette Transporters
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Bacteriocins
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DNA Primers
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mutacin IV