Analytical methodology for assessment of food allergens: opportunities and challenges

Biotechnol Adv. 2005 Sep;23(6):415-22. doi: 10.1016/j.biotechadv.2005.05.007.

Abstract

This review summarizes the available in vitro, in vivo, and informatic methods designed to evaluate different aspects of the capacity of proteins to act as true food allergens. By now, there is no single method to fully assess the potential allergenicity of proteins. The characterization of many food allergens will help to uncover the sequential and structural motifs that determine the behaviour of proteins as food allergens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Allergens / analysis*
  • Allergens / immunology*
  • Amino Acid Sequence
  • Food Analysis / methods*
  • Food Hypersensitivity / diagnosis*
  • Food Hypersensitivity / immunology*
  • Immunoassay / methods*
  • Immunoglobulin E / immunology*
  • Molecular Sequence Data
  • Plant Proteins / analysis
  • Plant Proteins / immunology

Substances

  • Allergens
  • Plant Proteins
  • Immunoglobulin E