Abstract
A novel stereospecific synthetic route to obtain a series of 2,5-disubstituted-dioxacycloalkanes is reported. Using an in vivo inhibition assay by monitoring xylene-induced ear edema in mice, the structure-activity relationship of the dioxacycloalkane compounds was studied, and compounds possessing high anti-inflammatory activity were identified.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemical synthesis*
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Anti-Inflammatory Agents / pharmacology*
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Cycloparaffins / chemical synthesis*
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Cycloparaffins / pharmacology*
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Ear Diseases / chemically induced
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Ear Diseases / prevention & control
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Edema / chemically induced
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Edema / prevention & control
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Male
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Mice
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Mice, Inbred Strains
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Molecular Conformation
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Stereoisomerism
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Structure-Activity Relationship
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Xylenes / antagonists & inhibitors
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Xylenes / chemistry
Substances
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Anti-Inflammatory Agents
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Cycloparaffins
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Xylenes