Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT7 receptor ligands

Magalie Paillet-Loilier; Frédéric Fabis; Alban Lepailleur; Ronan Bureau; Sabrina Butt-Gueulle; François Dauphin; Catherine Delarue; Hubert Vaudry; Sylvain Rault

doi:10.1016/j.bmcl.2005.05.059

Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT7 receptor ligands

Bioorg Med Chem Lett. 2005 Aug 15;15(16):3753-7. doi: 10.1016/j.bmcl.2005.05.059.

Authors

Magalie Paillet-Loilier¹, Frédéric Fabis, Alban Lepailleur, Ronan Bureau, Sabrina Butt-Gueulle, François Dauphin, Catherine Delarue, Hubert Vaudry, Sylvain Rault

Affiliation

¹ Centre d'Etudes et de Recherche sur le Médicament de Normandie, Université de Caen, UFR des Sciences Pharmaceutiques, 5, rue Vaubénard 14032 Caen Cedex, France.

PMID: 16002287
DOI: 10.1016/j.bmcl.2005.05.059

Abstract

Virtual screening studies have identified a series of phenylpyrroles as novel 5-HT7 receptor ligands. The synthesis and the affinity for the 5-HT7 receptor of these phenylpyrroles are described. Some of these compounds exhibited high affinity for the 5-HT7 receptors.

MeSH terms

Animals
Binding, Competitive / drug effects
Drug Evaluation, Preclinical
Humans
Ligands
Molecular Structure
Pyrroles / chemical synthesis
Pyrroles / classification*
Pyrroles / pharmacology*
Rats
Receptors, Serotonin / drug effects*
Structure-Activity Relationship

Substances

Ligands
Pyrroles
Receptors, Serotonin
serotonin 7 receptor