Abstract
We show the unprecedented one-pot synthesis of a large suite of pyrimidines (including cytosine and uracil) and purines from formamide in the presence of cosmic-dust analogues (CDAs) of olivines. Since the major problem in the origin of informational macromolecules is the instability of their precursors, we also investigate the stabilizing effect of CDAs on the intrinsic instability of oligonucleotides in formamide.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Cosmic Dust*
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Cytosine / chemical synthesis
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Cytosine / metabolism
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Formamides / chemistry
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Formamides / pharmacology*
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Iron Compounds / chemistry
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Magnesium Compounds / chemistry
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Magnesium Silicates / chemistry
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Magnesium Silicates / pharmacology
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Mass Spectrometry
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Microscopy, Electron, Scanning
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Nucleic Acids / chemical synthesis*
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Nucleic Acids / metabolism*
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Oligonucleotides / metabolism
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Purines / chemical synthesis*
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Purines / chemistry
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Silicates / chemistry
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Uracil / chemical synthesis
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Uracil / metabolism
Substances
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Cosmic Dust
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Formamides
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Iron Compounds
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Magnesium Compounds
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Magnesium Silicates
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Nucleic Acids
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Oligonucleotides
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Purines
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Silicates
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formamide
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Uracil
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Cytosine
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olivine