Myxofibrosarcoma (myxoid malignant fibrous histiocytoma) showing cutaneous presentation: report of two cases

J Cutan Pathol. 2005 Aug;32(7):512-5. doi: 10.1111/j.0303-6987.2005.00368.x.

Abstract

Myxofibrosarcoma or myxoid malignant fibrous histiocytoma is one of the most common fibroblastic sarcomas in older patients. It is characterized by a tendency for predominantly subcutaneous, multinodular, diffusely infiltrative growth, which may extend to the overlying dermis and present as a cutaneous lesion. Histologically, it comprises a spectrum ranging from hypocellular low-grade myxoid to high-grade pleomorphic sarcoma. Because the dermal presentation usually appears relatively banal, accurate diagnosis is sometimes challenging. In this report, we present two cases of myxofibrosarcoma with dermal involvement.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biomarkers, Tumor / analysis
  • Diagnosis, Differential
  • Disease-Free Survival
  • Female
  • Histiocytoma, Benign Fibrous / chemistry
  • Histiocytoma, Benign Fibrous / pathology*
  • Histiocytoma, Benign Fibrous / therapy
  • Humans
  • Immunohistochemistry / methods
  • Male
  • Mucins / analysis
  • Radiotherapy, Adjuvant
  • Skin Neoplasms / chemistry
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / therapy
  • Soft Tissue Neoplasms / chemistry
  • Soft Tissue Neoplasms / pathology*
  • Soft Tissue Neoplasms / therapy
  • Treatment Outcome

Substances

  • Biomarkers, Tumor
  • Mucins