Abstract
Multiple classes of proteins are modified to tailor them for specific physiological roles. The nature of these posttranslational modifications of proteins, as well as the relationships between them including those of the immune system proteins themselves, and immune system responses are reviewed. Aspects of protein posttranslational modification and their relationship to the pathogenesis of several autoimmune diseases and primary biliary cirrhosis are highlighted.
MeSH terms
-
Animals
-
Autoantigens / chemistry
-
Autoantigens / immunology*
-
Autoimmune Diseases / immunology*
-
Dihydrolipoyllysine-Residue Acetyltransferase
-
Enzymes / immunology
-
Humans
-
Liver Cirrhosis, Biliary / etiology
-
Liver Cirrhosis, Biliary / immunology*
-
Protein Processing, Post-Translational*
-
Proteins / immunology
-
Pyruvate Dehydrogenase Complex / chemistry
-
Pyruvate Dehydrogenase Complex / immunology*
Substances
-
Autoantigens
-
Enzymes
-
Proteins
-
Pyruvate Dehydrogenase Complex
-
Dihydrolipoyllysine-Residue Acetyltransferase