Abstract
CD8(+) T lymphocytes are thought to play an important role in the control of acute and chronic human immunodeficiency virus infections. However, there is a significant delay between infection and the first observed increase in virus-specific CD8(+) T-cell numbers. Prior to this time, viral kinetics are not significantly different between controls and vaccinees. Surprisingly, higher initial virus-specific CD8(+) T-cell numbers lead to a longer delay prior to initial CD8(+) T-cell expansion, and slower CD8(+) T-cell increases. Nevertheless, higher initial CD8(+) T-cell numbers were associated with reduced peak and chronic viral loads and reduced CD4(+) T-cell depletion.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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AIDS Vaccines / adverse effects
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AIDS Vaccines / immunology*
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Animals
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CD8-Positive T-Lymphocytes / immunology*
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HIV-1 / immunology*
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HIV-1 / isolation & purification*
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Lymphocyte Count
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Macaca
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Reassortant Viruses / immunology
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Reassortant Viruses / isolation & purification
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Simian Acquired Immunodeficiency Syndrome / immunology*
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Simian Acquired Immunodeficiency Syndrome / virology*
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Simian Immunodeficiency Virus / immunology*
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Simian Immunodeficiency Virus / isolation & purification
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T-Cell Antigen Receptor Specificity
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Vaccination*
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Viral Load