In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions

J Appl Toxicol. 2005 Jul-Aug;25(4):296-300. doi: 10.1002/jat.1065.

Abstract

In our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI-6, trimedoxime, BI-6 and Hlö-7) for reactivation of sarin- and cyclosarin-inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme. All oximes are able to reactivate sarin-inhibited AChE. On the other hand, only HI-6 is able to reactivate satisfactorily cyclosarin-inhibited AChE.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / enzymology
  • Chemical Warfare Agents / toxicity*
  • Cholinesterase Inhibitors / toxicity*
  • Cholinesterase Reactivators / pharmacology*
  • Kinetics
  • Organophosphorus Compounds / toxicity*
  • Rats
  • Rats, Wistar
  • Sarin / toxicity*

Substances

  • Chemical Warfare Agents
  • Cholinesterase Inhibitors
  • Cholinesterase Reactivators
  • Organophosphorus Compounds
  • Sarin
  • cyclohexyl methylphosphonofluoridate