Abstract
This article reports on the preparation of acryloylated bovine serum albumin microspheres and the evaluation of their employment in drug delivery areas. The influence of preparation parameters on albumin microspheres and the chemicophysical properties of loaded drugs were investigated. In particular, we focussed on acylation albumin degree and the amount of acryloylated albumin against comonomer in the polymerization step. Finally the release profile took into consideration the interaction drug-matrix, the fuctionalization degree of albumin, and the water affinity of matrix.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic beta-Antagonists / administration & dosage
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Adrenergic beta-Antagonists / chemistry
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Adrenergic beta-Antagonists / pharmacokinetics
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Animals
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Cattle
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Cross-Linking Reagents / chemistry
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Drug Delivery Systems / methods*
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Fluorouracil / administration & dosage
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Fluorouracil / chemistry
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Fluorouracil / pharmacokinetics
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Hydrogen-Ion Concentration
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / chemistry
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Immunosuppressive Agents / pharmacokinetics
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Microscopy, Electron, Scanning
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Microspheres*
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Pharmaceutical Preparations / administration & dosage*
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Pharmaceutical Preparations / chemistry
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Propranolol / administration & dosage
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Propranolol / chemistry
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Propranolol / pharmacokinetics
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Serum Albumin, Bovine / chemistry*
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Technology, Pharmaceutical / methods
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Time Factors
Substances
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Adrenergic beta-Antagonists
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Cross-Linking Reagents
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Immunosuppressive Agents
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Pharmaceutical Preparations
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Serum Albumin, Bovine
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Propranolol
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Fluorouracil