Cellular and molecular mechanisms in early hematopoietic differentiation

U Testa; M Valtieri; A Carè; E Pelosi; M Gabbianelli; E Montesoro; N M Sposi; D Bulgarini; A Camagna; G Isacchi

Cellular and molecular mechanisms in early hematopoietic differentiation

Leukemia. 1992:6 Suppl 3:146S.

Authors

U Testa¹, M Valtieri, A Carè, E Pelosi, M Gabbianelli, E Montesoro, N M Sposi, D Bulgarini, A Camagna, G Isacchi, et al.

Affiliation

¹ Department of Hematology-Oncology, Istituto Superiore di Sanità, Rome, Italy.

PMID: 1602812

Abstract

Recently developed methodology allows virtually complete purification and abundant recovery of hematopoietic progenitors from human adult peripheral blood (PB) (1). We have recently utilized the population of stringently purified progenitors to investigate cellular and molecular mechanisms underlying the early steps of hematopoietic differentiation. Three aspects of these studies are briefly reported here.

Publication types

Review

MeSH terms

Cell Differentiation
Colony-Forming Units Assay / methods*
Cross Reactions
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism*
Erythrocytes / metabolism*
Erythroid-Specific DNA-Binding Factors
Granulocytes / metabolism*
RNA, Messenger / metabolism*
Receptors, Colony-Stimulating Factor / metabolism*
Transcription Factors / genetics
Transcription Factors / metabolism*

Substances

DNA-Binding Proteins
Erythroid-Specific DNA-Binding Factors
RNA, Messenger
Receptors, Colony-Stimulating Factor
Transcription Factors