Interaction of large granular lymphocytes with susceptible target does not induce second messenger and cytolytic granule exocytosis

F Pollis; A Rosato; V Bronte; S Mandruzzato; A Zambon; R Zambello; P Pizzo; P Zanovello

Interaction of large granular lymphocytes with susceptible target does not induce second messenger and cytolytic granule exocytosis

Leukemia. 1992:6 Suppl 3:92S-93S.

Authors

F Pollis¹, A Rosato, V Bronte, S Mandruzzato, A Zambon, R Zambello, P Pizzo, P Zanovello

Affiliation

¹ Institute of Oncology, Inter-University Center for Cancer Research, University of Padova, Italy.

PMID: 1602835

Abstract

We studied the activation signals of LGL, from LDGL patients, following incubation with susceptible K562 target cells. The findings showed that LGL lysis is independent of [Ca2+]i rise and cytolytic granule exocytosis, and most likely involves alternative, as yet unidentified, mechanisms.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Calcium / metabolism*
Cells, Cultured
Granzymes
Humans
Lymphoproliferative Disorders / classification
Lymphoproliferative Disorders / metabolism*
Second Messenger Systems*
Serine Endopeptidases / metabolism
T-Lymphocytes, Cytotoxic / physiology*

Substances

Granzymes
Serine Endopeptidases
GZMA protein, human
Calcium