Randomized controlled trial of vaginal misoprostol versus vaginal misoprostol and isosorbide dinitrate for termination of pregnancy at 13-29 weeks

Samir Hidar; Mohamed Bouddebous; Anouar Chaïeb; Mehdi Jerbi; Mohamed Bibi; Hédi Khaïri

doi:10.1007/s00404-005-0053-7

Randomized controlled trial of vaginal misoprostol versus vaginal misoprostol and isosorbide dinitrate for termination of pregnancy at 13-29 weeks

Arch Gynecol Obstet. 2005 Dec;273(3):157-60. doi: 10.1007/s00404-005-0053-7. Epub 2005 Jul 24.

Authors

Samir Hidar¹, Mohamed Bouddebous, Anouar Chaïeb, Mehdi Jerbi, Mohamed Bibi, Hédi Khaïri

Affiliation

¹ Department of Obstetrics and Gynaecology, Farhat Hached University Teaching Hospital, 4002, Sousse, Tunisia. [email protected]

PMID: 16041629
DOI: 10.1007/s00404-005-0053-7

Abstract

When compared to the use of 12 hourly 200 microg vaginal misoprostol on its own, the addition of a single dose of 5 mg did not significantly increase the abortion or delivery rate in pregnancy termination at 13-29 weeks gestation. All patients were given intravenous syntocinon at 30 mU/min from the first dose of misoprostol onwards.

Publication types

Randomized Controlled Trial

MeSH terms

Abortifacient Agents, Nonsteroidal / administration & dosage*
Abortion, Induced*
Administration, Intravaginal
Adult
Female
Humans
Isosorbide Dinitrate / administration & dosage*
Misoprostol / administration & dosage*
Nitric Oxide Donors / administration & dosage*
Pregnancy
Pregnancy Trimester, Second
Prospective Studies
Treatment Outcome

Substances

Abortifacient Agents, Nonsteroidal
Nitric Oxide Donors
Misoprostol
Isosorbide Dinitrate