Abstract
The maximum tolerated single dose of intravenous iron infusion and iron pharmacokinetics are not known in children and not clear in adults. The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity. A TDM consultant discusses the case in the context of toxicokinetic analysis. Because the maximum tolerated dose and pharmacokinetics of intravenous iron preparations are not known, their use in both adults and children should still be undertaken with caution.
Publication types
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Case Reports
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Clinical Conference
MeSH terms
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Anemia, Iron-Deficiency / diagnosis
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Anemia, Iron-Deficiency / drug therapy
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Chemical and Drug Induced Liver Injury*
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Child, Preschool
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Deferoxamine / therapeutic use
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Ferric Compounds / administration & dosage
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Ferric Compounds / adverse effects*
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Ferric Compounds / therapeutic use
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Ferric Oxide, Saccharated
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Gastrointestinal Diseases / chemically induced
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Gastrointestinal Diseases / complications
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Gastrointestinal Diseases / drug therapy
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Glucaric Acid
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Humans
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Infusions, Intravenous
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Liver Diseases / complications
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Liver Diseases / drug therapy
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Male
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Siderophores / therapeutic use
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Treatment Outcome
Substances
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Ferric Compounds
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Siderophores
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Ferric Oxide, Saccharated
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Deferoxamine
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Glucaric Acid