Abstract
We performed time-kill studies of antimicrobial combinations that included minocycline, cefotaxime, and ciprofloxacin with Vibrio vulnificus ATCC 27562. Cefotaxime-plus-ciprofloxacin combinations acted synergistically against V. vulnificus in vitro, and this combination regimen can be a good choice as the empirical treatment for suspected necrotizing fasciitis due to V. vulnificus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / pharmacology*
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Anti-Infective Agents / standards
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Cefotaxime / pharmacology*
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Ciprofloxacin / pharmacology*
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Colony Count, Microbial
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Drug Synergism
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Humans
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Microbial Sensitivity Tests / methods
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Minocycline / pharmacology
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Vibrio vulnificus / drug effects*
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Vibrio vulnificus / growth & development
Substances
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Anti-Infective Agents
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Ciprofloxacin
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Minocycline
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Cefotaxime