Abstract
In mice, subcutaneous administration of antibiotics that disrupt the anaerobic microflora (i.e., clindamycin, piperacillin-tazobactam, and ceftriaxone) facilitated in vitro growth of and toxin production by Clostridium difficile in cecal contents, whereas antibiotics that cause minimal disruption of the anaerobic microflora (i.e., levofloxacin, cefepime, and aztreonam) did not.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Anti-Bacterial Agents / administration & dosage*
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Bacteria, Anaerobic / drug effects
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Bacteria, Anaerobic / growth & development
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Bacterial Toxins / metabolism*
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Cecum / microbiology*
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Clostridioides difficile / drug effects
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Clostridioides difficile / growth & development*
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Clostridioides difficile / metabolism
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Enterocolitis, Pseudomembranous / microbiology
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Enterotoxins / metabolism*
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Female
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Humans
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Mice
Substances
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Anti-Bacterial Agents
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Bacterial Toxins
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Enterotoxins