This article focuses on the intersection of intimate partner violence (IPV), substance use, and HIV status among a sample of low-income urban women (n = 611). Differences emerged by drug type, categorization of IPV, and HIV status. Rates of IPV did not differ between HIV-negative and HIV-positive women, but differing rates of substance use were found to be highly significant. The relationship between IPV and drug use appeared to be stronger for HIV-negative women. Descriptive data capturing temporal relationships between substance abuse and IPV support continued examination of types of IPV separately. These findings indicate the need to create comprehensive intervention strategies to address all three issues.