Abstract
We report the case of a patient with severe partial epilepsy associated with a focal rolandic, pathologically proven, cortical dysplasia. By measuring intracellular calcium concentrations, functional antiglial non-glutamate receptor 3 (GluR3) autoantibodies were identified in the serum of this patient. Antineuronal autoantibodies, which interfere with GluR3-receptor function, also were detected. This observation provides new clues about the involvement of immunologic mechanisms in epileptic disorders.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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6-Cyano-7-nitroquinoxaline-2,3-dione / pharmacology
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Adolescent
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Adult
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Animals
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Autoantibodies / blood
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Autoantibodies / immunology*
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Calcium / analysis
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Cells, Cultured / drug effects
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Cerebral Cortex / abnormalities*
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Cerebral Cortex / pathology
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Child
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Child, Preschool
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Epilepsies, Partial / etiology
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Epilepsies, Partial / immunology*
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Female
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Glial Fibrillary Acidic Protein / metabolism
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Hippocampus / cytology
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Hippocampus / drug effects
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Humans
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In Vitro Techniques
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Infant
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Kainic Acid / pharmacology
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Magnetic Resonance Imaging
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Male
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Neuroglia / chemistry
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Neuroglia / immunology*
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Neurons / chemistry
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Neurons / immunology
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Rats
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Rats, Sprague-Dawley
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Receptors, AMPA / immunology
Substances
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Autoantibodies
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Glial Fibrillary Acidic Protein
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Receptors, AMPA
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glutamate receptor ionotropic, AMPA 3
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6-Cyano-7-nitroquinoxaline-2,3-dione
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Kainic Acid
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Calcium