12q13 abnormality in rhabdomyosarcoma. A nonrandom occurrence?

Cancer Genet Cytogenet. 1992 Jun;60(2):135-40. doi: 10.1016/0165-4608(92)90005-s.

Abstract

We describe two cases of rhabdomyosarcoma with a translocation involving 12q13 as the primary cytogenetic abnormality. Literature review of 35 cases has identified 3 other cases with this abnormality, and we speculate that this may be another nonrandom rearrangement in rhabdomyosarcoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Child
  • Chromosomes, Human, Pair 12*
  • Female
  • Humans
  • Male
  • Rhabdomyosarcoma / genetics*
  • Rhabdomyosarcoma / therapy
  • Soft Tissue Neoplasms / genetics*
  • Soft Tissue Neoplasms / therapy
  • Thigh
  • Translocation, Genetic / genetics*
  • Urinary Bladder Neoplasms / genetics*
  • Urinary Bladder Neoplasms / therapy