Pyrazolidine derivatives with heteroaryl urea as dipeptidyl peptidase IV inhibitors

Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1048-50. doi: 10.1248/cpb.53.1048.

Abstract

In the continuation of efforts to modify the structure of our novel DP-IV inhibitors, a series of pyrazolidine derivatives with heteroaryl urea was synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dipeptidyl Peptidase 4 / drug effects*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice
  • Mice, Inbred C57BL
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / pharmacology*
  • Pyrazoles / chemistry
  • Pyrazoles / pharmacology*

Substances

  • Protease Inhibitors
  • Pyrazoles
  • Dipeptidyl Peptidase 4