Predominance of rotavirus genotype G9 during the 1999, 2000, and 2002 seasons among hospitalized children in the city of Salvador, Bahia, Brazil: implications for future vaccine strategies

J Clin Microbiol. 2005 Aug;43(8):4064-9. doi: 10.1128/JCM.43.8.4064-4069.2005.

Abstract

Two hundred eight of 648 (32%) diarrheal stool samples collected from hospitalized children under 5 years of age during a 3-year period (1999, 2000, and 2002) in the city of Salvador, in the state of Bahia, Brazil, were rotavirus positive. One hundred sixty-four of 208 (78.8%) rotavirus-positive samples had genotype G9 specificity, predominantly in association with P[8]. Other specificities detected were G1 (12.0%) and G4 (1.4%). Viruses with G2, G3, or P[4] specificity were not detected. Rotavirus genotype G9 predominated during each of the three seasons studied; it represented 89.2% of rotavirus strains detected in 1999, 85.3% in 2000, and 74.5% in 2002. G1 viruses (the globally most common G type) have a unique epidemiological characteristic of maintaining predominance during multiple consecutive rotavirus seasons. We have shown in this study for the first time that the G9 viruses also have a similar epidemiological characteristic, albeit for a shorter period of surveillance. The next generation of rotavirus vaccines will need to provide adequate protection against disease caused by G9 viruses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • Diarrhea / prevention & control
  • Diarrhea / virology*
  • Genotype
  • Humans
  • Infant
  • Infant, Newborn
  • Rotavirus / classification*
  • Rotavirus / genetics
  • Rotavirus / isolation & purification
  • Rotavirus Infections / prevention & control
  • Rotavirus Vaccines / immunology*
  • Seasons
  • Time Factors

Substances

  • Rotavirus Vaccines