Abstract
Using protein expression profiling, the authors identified an upregulation of the chemokine B lymphocyte chemoattractant (BLC) in the CSF of patients with neuroborreliosis but not in patients with noninflammatory and various other inflammatory neurologic diseases. This upregulation was confirmed by ELISA, showing increased BLC levels in every neuroborreliosis patient while being undetectable in patients with noninflammatory neurologic diseases. These results point to BLC as a putative additional diagnostic marker for neuroborreliosis.
MeSH terms
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Adolescent
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Adult
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Aged
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Antibodies / analysis
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B-Lymphocytes / immunology
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Biomarkers / cerebrospinal fluid
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Cerebrospinal Fluid / chemistry
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Cerebrospinal Fluid / immunology*
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Chemokine CXCL13
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Chemokines, CXC / cerebrospinal fluid*
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Chemokines, CXC / immunology
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Child
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Child, Preschool
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Diagnosis, Differential
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Encephalitis / cerebrospinal fluid
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Encephalitis / diagnosis
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Encephalitis / immunology
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Enzyme-Linked Immunosorbent Assay
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Humans
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Lyme Neuroborreliosis / cerebrospinal fluid*
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Lyme Neuroborreliosis / diagnosis*
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Lyme Neuroborreliosis / immunology
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Lymphocyte Activation / immunology
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Meningitis / cerebrospinal fluid
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Meningitis / diagnosis
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Meningitis / immunology
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Middle Aged
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Multiple Sclerosis / cerebrospinal fluid
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Multiple Sclerosis / diagnosis
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Multiple Sclerosis / immunology
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Neuritis / cerebrospinal fluid
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Neuritis / diagnosis
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Neuritis / immunology
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Predictive Value of Tests
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Protein Array Analysis
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Up-Regulation / immunology
Substances
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Antibodies
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Biomarkers
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CXCL13 protein, human
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Chemokine CXCL13
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Chemokines, CXC