Abstract
The clinical diagnosis of Marchiafava-Bignami disease (MBD) can be difficult. Acute demyelination of the corpus callosum is characteristic of the disease. The authors report the use of MR diffusion-weighted imaging (DWI) in six cases of acute MBD. They show that apparent diffusion coefficient restriction of the corpus callosum and cortical lesions were associated with a higher mortality rate and more severe cognitive sequelae.
MeSH terms
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Adult
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Alcohol-Induced Disorders, Nervous System / complications
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Alcohol-Induced Disorders, Nervous System / mortality
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Alcohol-Induced Disorders, Nervous System / pathology*
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Alcoholism / complications
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Cerebral Cortex / drug effects
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Cerebral Cortex / pathology*
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Cerebral Cortex / physiopathology
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Cognition Disorders / chemically induced
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Cognition Disorders / mortality
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Cognition Disorders / pathology*
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Corpus Callosum / drug effects
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Corpus Callosum / pathology*
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Corpus Callosum / physiopathology
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Diffusion Magnetic Resonance Imaging
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Ethanol / adverse effects
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Female
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Humans
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Male
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Middle Aged
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Nerve Fibers, Myelinated / drug effects
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Nerve Fibers, Myelinated / pathology
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Neurodegenerative Diseases / complications
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Neurodegenerative Diseases / mortality
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Neurodegenerative Diseases / pathology*
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Predictive Value of Tests
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Prognosis
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Wallerian Degeneration / chemically induced
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Wallerian Degeneration / pathology
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Wallerian Degeneration / physiopathology