Pulse requirements for x-ray diffraction imaging of single biological molecules

Stefan P Hau-Riege; Richard A London; Gosta Huldt; Henry N Chapman

doi:10.1103/PhysRevE.71.061919

Pulse requirements for x-ray diffraction imaging of single biological molecules

Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Jun;71(6 Pt 1):061919. doi: 10.1103/PhysRevE.71.061919. Epub 2005 Jun 28.

Authors

Stefan P Hau-Riege¹, Richard A London, Gosta Huldt, Henry N Chapman

Affiliation

¹ Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, California 94551, USA.

PMID: 16089777
DOI: 10.1103/PhysRevE.71.061919

Abstract

In this paper we estimate the required pulse parameters for the future application of x-ray free electron lasers to imaging single biological molecules. The parameters are determined by a tradeoff between minimizing image degradation due to damage and maximizing the image signal-to-noise ratio. We discuss several means to alleviate the pulse requirements, and compare the requirements with parameters of two planned x-ray lasers.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Biopolymers / analysis
Biopolymers / chemistry*
Biopolymers / radiation effects*
Computer Simulation
Linear Energy Transfer
Models, Chemical*
Molecular Conformation / radiation effects
Particle Size
X-Ray Diffraction / methods*
X-Rays

Substances

Biopolymers