Auditory brainstem response and otoacoustic emission assessment of hearing-impaired children of mothers who contracted rubella during pregnancy

Acta Otolaryngol. 2005 May;125(5):492-4. doi: 10.1080/00016480510036420.

Abstract

Conclusions: Based on the auditory brainstem response (ABR) results obtained in this study, the incidence of deafness in children whose mothers had rubella during pregnancy is high (29.5%), and deafness is profound in most cases (80%). Vaccinating women of childbearing age against rubella is essential to reduce the number of cases of childhood sensorineural hearing loss caused by gestational rubella.

Objective: It has been shown in the literature that, in Brazil, gestational rubella is responsible for approximately 21% of cases of deafness in children. The purpose of this study was to assess the incidence of deafness in children whose mothers had rubella during pregnancy.

Material and methods: Between February and July 2001, we conducted a prospective study assessing hearing status in 17 children (mean age 6 months). The mothers had serologically (ELISA) confirmed gestational rubella. We recorded ABRs and analysed distortion product otoacoustic emissions (DPOAEs).

Results: In 5 children (29.5%), ABRs revealed sensorineural hearing loss, which was moderate to severe in 1 (20%) and profound in 4 (80%). The hearing loss was bilateral in 3 children (60%) and asymmetrical in 4 (80%). Regarding DPOAEs, 7 children (41%) presented no response, and this occurred bilaterally in 4 (57%). All children with abnormal ABRs also presented abnormal DPOAEs. Two children with normal ABRs presented abnormal DPOAEs.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Evoked Potentials, Auditory, Brain Stem / physiology*
  • Female
  • Hearing Loss, Sensorineural / diagnosis
  • Hearing Loss, Sensorineural / etiology*
  • Hearing Loss, Sensorineural / surgery*
  • Humans
  • Infant
  • Male
  • Otoacoustic Emissions, Spontaneous / physiology*
  • Pregnancy
  • Pregnancy Complications*
  • Prenatal Exposure Delayed Effects*
  • Prospective Studies
  • Rubella / complications*
  • Severity of Illness Index