Abstract
Structures of many of the cell surface receptor-ligand complexes mediating the interactions between T cells and target cells have been determined in the past ten years. While snapshots of T cell receptors bound to their peptide-MHC ligands appear to have defined a general interaction or "docking" solution, many of the most fundamental structural questions in antigen recognition lack detailed answers and thus pose exciting experimental challenges for the future.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens / chemistry*
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Antigens / immunology
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Antigens / metabolism
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Cross Reactions / physiology
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Histocompatibility Antigens / immunology
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Histocompatibility Antigens / metabolism
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Humans
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Ligands
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Protein Structure, Tertiary*
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Receptors, Antigen, T-Cell / chemistry*
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Receptors, Antigen, T-Cell / immunology
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Receptors, Antigen, T-Cell / metabolism
Substances
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Antigens
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Histocompatibility Antigens
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Ligands
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Receptors, Antigen, T-Cell