1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors

Bioorg Med Chem Lett. 2005 Oct 15;15(20):4604-10. doi: 10.1016/j.bmcl.2005.06.064.

Abstract

A series of 1,8-naphthyridine derivatives bearing various substituents in position 3, 4, and 7 of the heterocyclic nucleus have been synthesized and evaluated for their affinity at the bovine and human adenosine receptors. The new compounds were found to lack the affinity toward A(1)AR, whereas many of them are able to acquire an interesting affinity and selectivity for the A(2A)AR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle
  • Humans
  • Hydrogen Bonding
  • Models, Molecular
  • Naphthyridines / metabolism*
  • Receptor, Adenosine A2A / metabolism*

Substances

  • Naphthyridines
  • Receptor, Adenosine A2A