Identification of a new HLA-B variant, HLA-B*5615

S Frison; E Longhi; A E de Arias; E Andreini; M Scalamogna; F Poli

doi:10.1111/j.1399-0039.2005.00458.x

Identification of a new HLA-B variant, HLA-B*5615

Tissue Antigens. 2005 Sep;66(3):238-9. doi: 10.1111/j.1399-0039.2005.00458.x.

Authors

S Frison¹, E Longhi, A E de Arias, E Andreini, M Scalamogna, F Poli

Affiliation

¹ Dipartimento Trasfusionale e di Riferimento per i Trapianti di Organi, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena-Fondazione IRCCS di Natura Pubblica, Milano, Italy.

PMID: 16101835
DOI: 10.1111/j.1399-0039.2005.00458.x

Abstract

A new HLA-B allele, B*5615, has been identified in a Caucasian individual by sequence-based typing. This allele shows a sequence identical to that of HLA-B*5601 except for two nucleotide substitutions that cause a change from TTA to TAC at codon 116 and an amino acidic change from Leucine to Tyrosine in the mature protein.

MeSH terms

Alleles*
Base Sequence
Codon
Exons
Female
HLA-B Antigens / genetics*
Histocompatibility Testing
Homozygote
Humans
Leucine / genetics
Molecular Sequence Data
Point Mutation
Sequence Analysis, DNA
Sequence Homology, Nucleic Acid
Tyrosine / genetics

Substances

Codon
HLA-B Antigens
HLA-B*56:15 antigen
Tyrosine
Leucine