Abstract
Neutrophil-derived serine proteases play an important role in fighting infections. However, emerging data suggest that these proteases also regulate noninfectious inflammatory responses. Loss-of-function mutations in serine proteases have provided critical insights into the significance of these serine proteases in initiating and amplifying immune complex-mediated diseases.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Movement
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Chemotaxis, Leukocyte
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Cytoplasmic Granules / enzymology
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Humans
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Immune Complex Diseases / enzymology*
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Immune Complex Diseases / immunology*
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Infections / enzymology
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Infections / immunology
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Inflammation / enzymology
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Inflammation / immunology
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Mice
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Neutrophils / enzymology*
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Neutrophils / immunology*
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Serine Endopeptidases / immunology*