A straightforward approach towards thiazoles and endothiopeptides via Ugi reaction

Org Biomol Chem. 2005 Sep 7;3(17):3184-7. doi: 10.1039/b507028g. Epub 2005 Jul 26.

Abstract

Endothiopeptides can easily be obtained via Ugi reaction using thio acids as acid components. If isonitriles with an acetal group are applied, the endothiopeptides can directly be converted into thiazoles using TMSCl-NaI under microwave irradiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Microwaves
  • Molecular Structure
  • Peptides / chemical synthesis*
  • Peptides / chemistry
  • Peptides / radiation effects
  • Stereoisomerism
  • Thiazoles / chemical synthesis*

Substances

  • Peptides
  • Thiazoles