Abstract
We developed a transgenic (Tg) rat model that overexpresses human proadrenomedullin N-terminal 20 peptide (PAMP) only and then compared the effects of unilateral nephrectomy followed by a high salt diet for five weeks in Tg and wild-type rats. We found that systolic blood pressure was significantly lower in Tg UNX rats and cardiac hypertrophy and myocardial fibrosis was also attenuated in Tg rats. Evaluation of gene expression showed suppression of cardiac local renin-angiotensin system (RAS) in Tg rat. These results suggest that in addition to reducing blood pressure, PAMP suppresses cardiac hypertrophy through negative regulation of the local cardiac RAS.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenomedullin
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Animals
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Animals, Genetically Modified
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Blood Pressure / physiology*
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Cardiomegaly / metabolism
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Cardiomegaly / pathology*
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Diet
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Fibrosis / pathology
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Humans
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Hypertension / metabolism*
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Kidney / cytology
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Kidney / pathology
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Myocardium / cytology
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Myocardium / metabolism
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Myocardium / pathology*
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Peptide Fragments / genetics
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Peptide Fragments / metabolism*
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Protein Precursors / genetics
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Protein Precursors / metabolism*
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Proteins / genetics
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Proteins / metabolism*
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Rats
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Renin-Angiotensin System / physiology
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Salts / administration & dosage
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Transgenes
Substances
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Peptide Fragments
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Protein Precursors
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Proteins
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Salts
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proadrenomedullin
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Adrenomedullin