Abstract
The authors sought to identify clinical and MRI predictors of outcome in primary progressive multiple sclerosis (PPMS). Clinical and MRI assessments were performed at baseline and 2 and 5 years (clinical only). At baseline, disease duration, expanded disability status scale (EDSS) and brain volume predicted outcome. Adding short-term change variables, baseline EDSS, changes in T2* lesion load and cord area, and number of new lesions were predictive. Clinical and MRI variables predict long-term outcome in PPMS.
Publication types
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Comparative Study
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Atrophy / pathology
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Brain / pathology
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Brain / physiopathology
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Central Nervous System / pathology*
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Central Nervous System / physiopathology
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Cohort Studies
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Data Collection
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Diffusion Magnetic Resonance Imaging / standards
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Disability Evaluation
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Disease Progression
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Humans
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Longitudinal Studies
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Magnetic Resonance Imaging / methods
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Magnetic Resonance Imaging / standards
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Magnetic Resonance Imaging / statistics & numerical data*
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Multiple Sclerosis, Chronic Progressive / diagnosis*
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Multiple Sclerosis, Chronic Progressive / pathology*
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Multiple Sclerosis, Chronic Progressive / physiopathology
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Nerve Fibers, Myelinated / pathology
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Neurologic Examination
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Predictive Value of Tests
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Prognosis
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Prospective Studies
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Spinal Cord / pathology
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Spinal Cord / physiopathology
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Time Factors