Abstract
T cell circulation between peripheral tissues and the lymphoid compartment is critical for immunosurveillance and host defense. However, the factors that determine whether T cells remain in peripheral tissue or return to the circulation are undefined. Here we demonstrate that the chemokine receptor CCR7 is a critical signal that determines T cell exit from peripheral tissue. Both CCR7(-) and CCR7(+) effector T cells entered mouse asthmatic lung and while CCR7(-) T cells accumulated, CCR7(+) T cells continued to migrate into afferent lymph. Delivery of both CCR7(+) and CCR7(-) T cells directly into the airways showed that only CCR7(+) T cells exited the lung and entered draining lymph nodes. Our study establishes a molecular basis for T cell exit from peripheral tissues.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Asthma / chemically induced
-
Asthma / immunology
-
Bronchoalveolar Lavage Fluid / immunology
-
CD4-Positive T-Lymphocytes / immunology
-
CD4-Positive T-Lymphocytes / metabolism
-
CD8-Positive T-Lymphocytes / immunology
-
CD8-Positive T-Lymphocytes / metabolism
-
Cell Proliferation
-
Chemotaxis, Leukocyte / immunology*
-
Inflammation / immunology
-
Lung / pathology
-
Lymph / immunology
-
Lymph / metabolism
-
Lymph Nodes / immunology
-
Lymph Nodes / metabolism
-
Mice
-
Mice, Inbred C57BL
-
Mice, Transgenic
-
Receptors, CCR7
-
Receptors, Chemokine / deficiency
-
Receptors, Chemokine / immunology*
-
Receptors, Chemokine / metabolism
-
T-Lymphocytes / immunology*
-
T-Lymphocytes / metabolism
Substances
-
Ccr7 protein, mouse
-
Receptors, CCR7
-
Receptors, Chemokine