Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23

F Galland; M Stefanova; M Lafage; D Birnbaum

doi:10.1159/000133316

Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23

Cytogenet Cell Genet. 1992;60(2):114-6. doi: 10.1159/000133316.

Authors

F Galland¹, M Stefanova, M Lafage, D Birnbaum

Affiliation

¹ U.119 INSERM, Marseille, France.

PMID: 1611909
DOI: 10.1159/000133316

Abstract

Oncogenic activation of the MCF.2 cell line-derived transforming sequence gene (MCF2) occurs through substitution of part of its 5' coding region by unrelated nonsyntenic sequences. Analysis of the MCF2 oncogene locus revealed complex recombination events involving four discontinuous human DNA segments. The upstream replacing sequence, named URS, represents the farthest 5' portion of the locus. The URS sequence maps to the D15S93 locus on human chromosome 15q15----q23.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Chromosomes, Human, Pair 15*
Humans
Molecular Sequence Data
Oncogenes / genetics*
Recombination, Genetic / genetics
Restriction Mapping