[Expression and significance of EBV LMP2A in nasopharyngeal cancer specimens]

Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Jun;19(11):484-7.
[Article in Chinese]

Abstract

Objective: To investigate the expression of Epstein-Barr Virus (EBV) latent membrane protein 2A (LMP2A) in tumor tissues of nasopharyngeal cancer (NPC) and discuss the possibility (feasibility) that LMP2A was selected (to select <of selecting> LMP2A ) as a target antigen in immunologic treatment of NPC.

Method: The expression of EBV LMP2A was detected in the specimens of 40 patients with NPC and 38 cases with nasopharyngeal inflammation by S-P immunohistochemical methods.

Result: Of the 40 NPC specimens, 36 cases expressed LMP2A. There was no significant relationship between the expression of LMP2A and the histological differentiation of NPC. Thirty-three of the 38 cases with nasopharyngeal inflammation showed negative expression of LMP2A. There was a significant difference of LMP2A expression between NPC and nasopharyngeal inflammation.

Conclusion: The expression of EBV LMP2A is confirmed in the NPC specimens,and the negative results are seen in the majority of the inflammation cases. There is a possibility of applying LMP2A target antigen to induce specific immunoreaction to kill tumor cells of NPC.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Carcinoma, Squamous Cell / immunology*
  • Carcinoma, Squamous Cell / metabolism
  • Carcinoma, Squamous Cell / virology*
  • Female
  • Herpesvirus 4, Human / immunology
  • Humans
  • Male
  • Middle Aged
  • Nasal Mucosa / pathology
  • Nasopharyngeal Neoplasms / immunology*
  • Nasopharyngeal Neoplasms / metabolism
  • Nasopharyngeal Neoplasms / virology*
  • Viral Matrix Proteins / immunology
  • Viral Matrix Proteins / metabolism*
  • Young Adult

Substances

  • EBV-associated membrane antigen, Epstein-Barr virus
  • Viral Matrix Proteins